Yes! Berryman B-12 CHEMTOOL FUEL SYSTEM CLEANER (part #0116) is compatible with all materials of construction in your 2016 Sonata’s fuel system, and the product will treat 15-21 gallons of conventional and E10 gasolines. Additionally, starting a regular maintenance program like using B-12 once every third fill-up while your vehicle is still low-mileage will help prolong the life of critical fuel system components like the fuel pump and fuel injectors.